NLRC3

Across TCGA patient cohorts, NLRC3 mutation is significantly associated with the RNA expression of many other genes, with 4,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRC3-associated genes across cancer lineages are CNOT7, IER3IP1, and TAF9. Each is linked with NLRC3 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRC3-to-partner and partner-to-NLRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNOT7 grouped by NLRC3-low versus NLRC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC3→partner) and Y-score (partner→NLRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CNOT7 →	+0.424	+1.966	.002	.002	3	4
COAD	IER3IP1 →	+0.531	+3.797	<.001	<.001	3	4
UCEC	TAF9 →	+0.655	+1.999	<.001	<.001	3	3
KIRP	HAUS1P3 →	+0.086	+5.628	.002	.004	3	3
COAD	EVL →	-0.560	-3.439	.005	.005	3	3
HNSC	LINC01399 →	+0.286	+3.793	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,615 associations by consensus.

CNOT7 by NLRC3 expression — UCEC

Explore this box plot interactively →