NLN

Across TCGA cell cohorts, NLN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLN-associated GO terms across cancer lineages are Positive regulation of rRNA processing, Transcription initiation at RNA polymerase I promoter, and Maturation of SSU-rRNA. Each is linked with NLN in more than 15 cancer types. Because this analysis shows association rather than direction, both NLN-to-partner and partner-to-NLN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of rRNA processing grouped by NLN-low versus NLN-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLN→partner) and Y-score (partner→NLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of rRNA processing →	+0.135	+1.163	.006	.006	3	16
PANCREAS	Transcription initiation at RNA polymerase I promoter →	+0.125	+1.087	<.001	<.001	3	14
BLOOD_Myeloma	Maturation of SSU-rRNA →	+0.123	+1.225	<.001	<.001	3	14
BLOOD_Myeloma	rRNA metabolic process →	+0.091	+1.113	.002	.001	3	13
LARGE_INTESTINE	Transcription by RNA polymerase I →	+0.120	+1.013	<.001	<.001	3	13
BLOOD_Myeloma	Ribosomal small subunit biogenesis →	+0.087	+0.858	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,112 associations by consensus.

Positive regulation of rRNA processing by NLN expression — OESOPHAGUS

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