NLN

Across TCGA pan-cancer cohorts, NLN RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated NLN data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NLN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NLN expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, UVM, and ACC are the cancer types where NLN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.727	0.511	<.001	100	view →
UVM	DFS	Quartile	All	0.266	0.844	<.001	95	view →
ACC	DFS	Tertile	All	0.425	0.824	<.001	89	view →
READ	DFS	Median	II,III,IV	0.697	0.346	<.001	88	view →
BLCA	DFS	Tertile	All	0.423	0.555	.004	66	view →
PAAD	DFS	Tertile	All	0.179	0.432	.001	43	view →
MESO	OS	Quartile	All	0.288	0.626	<.001	40	view →
BRCA	OS	Tertile	II,III,IV	0.472	0.647	<.001	35	view →
LGG	OS	Median	All	0.754	0.867	<.001	32	view →
LIHC	OS	Tertile	All	0.662	0.866	<.001	29	view →
STAD	OS	Quartile	All	0.398	0.668	.014	28	view →
SARC	DFS	Tertile	All	0.454	0.737	.001	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

NLN–KIRC (DFS)

Open the KIRC breakdown →