NLGN4Y

Across TCGA patient cohorts, NLGN4Y mutation is significantly associated with the RNA expression of many other genes, with 636 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NLGN4Y-associated genes across cancer lineages are TTTY13, ARSDP1, and HSFY4P. Each is linked with NLGN4Y in more than 2 cancer types. Because this analysis shows association rather than direction, both NLGN4Y-to-partner and partner-to-NLGN4Y results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY13 grouped by NLGN4Y-low versus NLGN4Y-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN4Y→partner) and Y-score (partner→NLGN4Y) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TTTY13 →	+0.195	+5.054	.003	.001	3	3
COAD	ARSDP1 →	+0.312	+2.447	.005	.006	3	3
READ	HSFY4P →	+0.048	+5.681	<.001	.001	3	2
COAD	ARSFP1 →	+0.206	+2.736	<.001	<.001	3	2
COAD	FAM8A4P →	+0.074	+3.048	<.001	<.001	3	2
COAD	ZFY-AS1 →	+0.405	+4.281	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 636 associations by consensus.

TTTY13 by NLGN4Y expression — READ

Explore this box plot interactively →