NLGN4X

Across TCGA patient cohorts, NLGN4X mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLGN4X-associated genes across cancer lineages are PCNA, cIAP, and Cyclin-E2. Each is linked with NLGN4X in more than 3 cancer types. Because this analysis shows association rather than direction, both NLGN4X-to-partner and partner-to-NLGN4X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by NLGN4X-low versus NLGN4X-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN4X→partner) and Y-score (partner→NLGN4X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PCNA →	+0.328	+3.700	.002	.001	3	4
LUSC	cIAP →	+0.087	+2.459	.024	.017	3	3
STAD	Cyclin-E2 →	+0.146	+1.758	.003	.045	3	3
STAD	FOXO3a_pS318_S321 →	-0.170	-2.300	.012	.005	3	3
STAD	RAD51 →	+0.302	+3.459	<.001	.004	3	3
UCEC	TIGAR →	+0.093	+1.081	.031	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

PCNA by NLGN4X expression — STAD

Explore this box plot interactively →