NLGN4X

Across TCGA pan-cancer cohorts, NLGN4X RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NLGN4X data layer compared with 11 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher NLGN4X RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NLGN4X expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

UVM, KIRC, and SKCM are the cancer types where NLGN4X RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.428	0.720	<.001	107	view →
KIRC	OS	Median	All	0.852	0.758	<.001	79	view →
SKCM	OS	Tertile	II,III,IV	0.929	0.758	.002	33	view →
CHOL	DFS	Tertile	II,III,IV	0.754	0.118	.006	28	view →
LUAD	DFS	Quartile	IV	0.358	0.825	.012	26	view →
HNSC	DFS	Quartile	All	0.223	0.527	.008	24	view →
LAML	DFS	Median	All	0.467	0.262	.004	22	view →
BRCA	OS	Quartile	IV	0.986	0.396	.008	18	view →
STAD	OS	Median	All	0.527	0.634	.012	17	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	17	view →
THCA	OS	Quartile	All	0.799	1.000	.013	17	view →
LGG	OS	Median	All	0.847	0.964	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NLGN4X–UVM (DFS)

Open the UVM breakdown →