NLGN4X

Across TCGA cell cohorts, NLGN4X mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLGN4X-associated genes across cancer lineages are FAM71B, XAGE3, and GSTA3. Each is linked with NLGN4X in more than 1 cancer types. Because this analysis shows association rather than direction, both NLGN4X-to-partner and partner-to-NLGN4X results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71B grouped by NLGN4X-low versus NLGN4X-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN4X→partner) and Y-score (partner→NLGN4X) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM71B →	+0.016	+5.060	<.001	.001	3	2
LUNG_NSCLC_LUAD	XAGE3 →	+0.065	+2.536	.001	.007	3	2
OVARY	GSTA3 →	+0.106	+5.339	<.001	<.001	3	2
CNS	TRIM42 →	+0.006	+5.321	<.001	.005	3	1
CNS	PFN3 →	+0.078	+5.754	<.001	.002	3	1
SKIN	RLN3 →	+0.037	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

FAM71B by NLGN4X expression — BLOOD_Leukemia

Explore this box plot interactively →