NLGN1

Across TCGA cell cohorts, NLGN1 mutation is significantly associated with the RNA expression of many other genes, with 590 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLGN1-associated genes across cancer lineages are CEACAM3, PIGY, and PSMB6. Each is linked with NLGN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLGN1-to-partner and partner-to-NLGN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM3 grouped by NLGN1-low versus NLGN1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLGN1→partner) and Y-score (partner→NLGN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CEACAM3 →	+0.053	+4.807	<.001	.006	3	2
BLOOD_Myeloma	PIGY →	+0.846	+4.807	.001	.006	3	2
LARGE_INTESTINE	PSMB6 →	+0.499	+2.588	.007	.004	3	2
LARGE_INTESTINE	LYG1 →	+0.858	+3.169	.001	.009	3	2
LARGE_INTESTINE	FAM124A →	+0.843	+2.474	<.001	.004	3	2
LARGE_INTESTINE	EN1 →	+0.824	+2.121	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 590 associations by consensus.

CEACAM3 by NLGN1 expression — BLOOD_Myeloma

Explore this box plot interactively →