NLE1

Across TCGA patient cohorts, NLE1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,658 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NLE1-associated genes across cancer lineages are TMEM97, HROB, and EME1. Each is linked with NLE1 in more than 7 cancer types. Because this analysis shows association rather than direction, both NLE1-to-partner and partner-to-NLE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NLE1 versus TMEM97 in LSCC, with a Pearson correlation of 0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLE1→partner) and Y-score (partner→NLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TMEM97 →	+1.144	+0.414	<.001	<.001	3	8
LUAD	HROB →	+0.998	+0.262	<.001	<.001	3	8
HNSC	EME1 →	+1.042	+0.339	<.001	<.001	3	8
LSCC	BRCA1 →	+0.957	+0.483	<.001	<.001	3	7
HNSC	TICRR →	+0.944	+0.330	<.001	<.001	3	7
HNSC	PARPBP →	+0.796	+0.315	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,658 associations by consensus.

NLE1 vs TMEM97 — LSCC

Explore this scatter interactively →