NLE1

Across TCGA patient cohorts, NLE1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLE1-associated genes across cancer lineages are Stathmin, PCNA, and eIF4E. Each is linked with NLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLE1-to-partner and partner-to-NLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by NLE1-low versus NLE1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLE1→partner) and Y-score (partner→NLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Stathmin →	+0.191	+2.815	.023	.036	3	2
COAD	PCNA →	+0.318	+2.815	.019	.036	2	2
UCEC	eIF4E →	+0.184	+3.321	.039	.010	3	1
UCEC	MEK1 →	+0.392	+2.584	.011	.010	3	1
UCEC	MSH2 →	-0.318	-2.312	.001	.034	3	1
UCEC	mTOR_pS2448 →	-0.161	-2.439	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Stathmin by NLE1 expression — COAD

Explore this box plot interactively →