NLE1

Across TCGA cell cohorts, NLE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,405 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NLE1-associated GO terms across cancer lineages are Maturation of 5.8S rRNA, Maturation of LSU-rRNA, and Nucleolar large rRNA transcription by RNA polymerase I. Each is linked with NLE1 in more than 19 cancer types. Because this analysis shows association rather than direction, both NLE1-to-partner and partner-to-NLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA grouped by NLE1-low versus NLE1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NLE1→partner) and Y-score (partner→NLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of 5.8S rRNA →	+0.112	+0.614	<.001	<.001	3	20
BONE	Maturation of LSU-rRNA →	+0.150	+0.609	.002	.001	3	20
LUNG_SCLC	Nucleolar large rRNA transcription by RNA polymerase I →	+0.154	+0.774	<.001	<.001	3	19
URINARY_TRACT	IMP biosynthetic process →	+0.242	+1.156	<.001	<.001	3	18
URINARY_TRACT	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.131	+1.057	<.001	<.001	3	18
BONE	'de novo' IMP biosynthetic process →	+0.206	+1.032	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,405 associations by consensus.

Maturation of 5.8S rRNA by NLE1 expression — BONE

Explore this box plot interactively →