NLE1

Across TCGA cell cohorts, NLE1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLE1-associated genes across cancer lineages are C1orf185, HMGCS1, and LHCGR. Each is linked with NLE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLE1-to-partner and partner-to-NLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf185 grouped by NLE1-low versus NLE1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLE1→partner) and Y-score (partner→NLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C1orf185 →	+0.063	+4.887	<.001	.009	3	1
LARGE_INTESTINE	HMGCS1 →	+1.215	+3.087	.001	.006	3	1
LARGE_INTESTINE	LHCGR →	+0.023	+3.204	.006	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1
LARGE_INTESTINE	GPR171 →	+0.011	+3.009	.003	.001	3	1
LARGE_INTESTINE	PRAMEF10 →	+0.307	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

C1orf185 by NLE1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →