NKX6-2

Across TCGA patient cohorts, NKX6-2 mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX6-2-associated genes across cancer lineages are MIR5591, VN1R36P, and RPS27P27. Each is linked with NKX6-2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NKX6-2-to-partner and partner-to-NKX6-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5591 grouped by NKX6-2-low versus NKX6-2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-2→partner) and Y-score (partner→NKX6-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR5591 →	+0.215	+4.148	<.001	.006	3	3
STAD	VN1R36P →	+0.171	+5.187	<.001	.007	3	2
UCEC	RPS27P27 →	+0.387	+2.429	<.001	.004	3	2
COAD	RNY4P23 →	+0.405	+3.717	.004	.008	3	1
COAD	RNU6-748P →	+0.642	+3.877	.004	.008	3	1
COAD	MTCYBP45 →	+0.281	+6.149	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

MIR5591 by NKX6-2 expression — UCEC

Explore this box plot interactively →