NKX6-2

Across TCGA pan-cancer cohorts, NKX6-2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated NKX6-2 data layer compared with 1 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher NKX6-2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NKX6-2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

BRCA, DLBC, and MESO are the cancer types where NKX6-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	II,III,IV	0.923	0.966	.002	45	view →
DLBC	OS	Tertile	II,III,IV	0.573	0.895	.011	36	view →
MESO	DFS	Tertile	IV	0.144	0.460	.002	36	view →
THCA	OS	Tertile	III,IV	0.917	1.000	.004	27	view →
ACC	OS	Median	All	0.712	0.867	.010	18	view →
UCEC	DFS	Median	IV	0.661	0.283	.008	18	view →
STAD	DFS	Median	III,IV	0.240	0.464	.009	17	view →
HNSC	OS	Median	All	0.310	0.405	.013	15	view →
KIRP	OS	Quartile	III,IV	0.129	0.701	.020	13	view →
KICH	DFS	Tertile	III,IV	0.353	0.865	.046	8	view →
KIRC	DFS	Tertile	IV	0.445	0.750	.026	8	view →
CHOL	OS	Median	III,IV	0.406	0.961	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

NKX6-2–BRCA (OS)

Open the BRCA breakdown →