NKX6-2

Across TCGA patient cohorts, NKX6-2 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX6-2-associated genes across cancer lineages are ACVRL1, MSH6, and ATM. Each is linked with NKX6-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX6-2-to-partner and partner-to-NKX6-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by NKX6-2-low versus NKX6-2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-2→partner) and Y-score (partner→NKX6-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.234	-2.986	.001	.035	3	1
UCEC	MSH6 →	-0.580	-2.999	<.001	.035	3	1
UCEC	ATM →	-0.739	-3.321	.001	.010	3	1
UCEC	Caspase-8 →	-0.316	-3.143	.016	.018	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ACVRL1 by NKX6-2 expression — UCEC

Explore this box plot interactively →