NKX6-1

Across TCGA pan-cancer cohorts, NKX6-1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NKX6-1 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NKX6-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NKX6-1 expression acts as an unfavorable survival marker.

HNSC, LUSC, and LUAD are the cancer types where NKX6-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.172	0.662	<.001	48	view →
LUSC	OS	Median	All	0.081	0.818	<.001	6	view →
LUAD	OS	Median	All	0.188	0.670	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NKX6-1–HNSC (OS)

Open the HNSC breakdown →