NKX3-2

Across TCGA patient cohorts, NKX3-2 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NKX3-2-associated genes across cancer lineages are MPV17L2P1, ZP4, and OR5M10. Each is linked with NKX3-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX3-2-to-partner and partner-to-NKX3-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPV17L2P1 grouped by NKX3-2-low versus NKX3-2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX3-2→partner) and Y-score (partner→NKX3-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MPV17L2P1 →	+0.044	+4.912	<.001	.003	3	2
SCLC	ZP4 →	+0.438	+4.847	<.001	.009	3	1
SCLC	OR5M10 →	+0.378	+6.228	<.001	.001	3	1
SKCM	ARF1P3 →	+0.119	+4.730	<.001	.003	3	1
SKCM	RN7SL690P →	+0.145	+4.771	<.001	.006	3	1
SKCM	RN7SL74P →	+0.222	+4.867	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

MPV17L2P1 by NKX3-2 expression — LUAD

Explore this box plot interactively →