NKX3-2

Across TCGA pan-cancer cohorts, NKX3-2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NKX3-2 data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NKX3-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX3-2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LAML show a favorable association.

KIRP, UVM, and ACC are the cancer types where NKX3-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.777	0.911	<.001	147	view →
UVM	OS	Median	All	0.406	0.782	<.001	126	view →
ACC	OS	Median	All	0.403	0.815	<.001	92	view →
LIHC	OS	Median	All	0.608	0.756	<.001	74	view →
LGG	OS	Median	All	0.344	0.553	<.001	51	view →
KIRC	DFS	Tertile	II,III,IV	0.416	0.610	.002	45	view →
SKCM	OS	Tertile	III,IV	0.889	0.549	.002	42	view →
KICH	DFS	Quartile	All	0.688	0.967	.004	32	view →
LAML	DFS	Tertile	All	0.674	0.498	.016	32	view →
ESCA	DFS	Tertile	All	0.895	0.359	.007	21	view →
LUSC	OS	Tertile	All	0.750	0.619	.003	19	view →
LUAD	DFS	Median	All	0.286	0.437	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NKX3-2–KIRP (DFS)

Open the KIRP breakdown →