NKX3-2

Across TCGA cell cohorts, NKX3-2 mutation is significantly associated with the mutation status of many other genes, with 2,917 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX3-2-associated genes across cancer lineages are MYLK2, CEP250, and CASKIN1. Each is linked with NKX3-2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NKX3-2-to-partner and partner-to-NKX3-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYLK2 grouped by NKX3-2-low versus NKX3-2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX3-2→partner) and Y-score (partner→NKX3-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYLK2 →	+4.321	+5.285	.005	.005	1	3
LUNG_NSCLC_LUAD	CEP250 →	+3.339	+4.662	.003	.003	1	3
LUNG_NSCLC_LUAD	CASKIN1 →	+4.339	+4.339	.009	.009	1	3
BLOOD_Leukemia	HOXB2 →	+6.321	+6.321	.001	.001	1	3
LUNG_NSCLC_LUAD	VWA3A →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	RGMA →	+5.339	+4.772	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,917 associations by consensus.

MYLK2 by NKX3-2 expression — BLOOD_Leukemia

Explore this box plot interactively →