NKX2-6

Across TCGA pan-cancer cohorts, NKX2-6 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated NKX2-6 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NKX2-6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NKX2-6 expression acts as an unfavorable survival marker.

UCEC are the cancer types where NKX2-6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

NKX2-6–UCEC (OS)

Open the UCEC breakdown →