NKX2-3

Across TCGA pan-cancer cohorts, NKX2-3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated NKX2-3 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher NKX2-3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX2-3 expression acts as an unfavorable survival marker.

LUSC are the cancer types where NKX2-3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

NKX2-3–LUSC (DFS)

Open the LUSC breakdown →