NKX2-2

Across TCGA patient cohorts, NKX2-2 mutation is significantly associated with the RNA expression of many other genes, with 4,129 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-2-associated genes across cancer lineages are ZBTB41, EYA3, and PGGT1B. Each is linked with NKX2-2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NKX2-2-to-partner and partner-to-NKX2-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB41 grouped by NKX2-2-low versus NKX2-2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-2→partner) and Y-score (partner→NKX2-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZBTB41 →	+0.529	+3.332	.004	.005	3	4
UCEC	EYA3 →	+0.502	+2.872	<.001	.001	3	3
UCEC	PGGT1B →	+0.571	+4.021	<.001	<.001	3	3
UCEC	FBXO33 →	+0.524	+3.939	<.001	<.001	3	3
UCEC	TSC1 →	+0.373	+3.721	<.001	<.001	3	3
UCEC	CRK →	+0.508	+3.939	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,129 associations by consensus.

ZBTB41 by NKX2-2 expression — UCEC

Explore this box plot interactively →