NKX2-2

Across TCGA pan-cancer cohorts, NKX2-2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NKX2-2 data layer compared with 4 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NKX2-2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX2-2 expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUAD show a favorable association.

KIRP, SKCM, and UVM are the cancer types where NKX2-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.727	1.000	<.001	74	view →
SKCM	OS	Quartile	III,IV	0.589	0.835	<.001	64	view →
UVM	DFS	Quartile	All	0.376	0.771	<.001	63	view →
BRCA	DFS	Quartile	II,III,IV	0.835	0.915	.002	49	view →
UCEC	DFS	Median	All	0.867	0.917	.003	48	view →
PAAD	DFS	Quartile	All	0.687	0.190	<.001	33	view →
CHOL	OS	Quartile	All	0.145	0.795	<.001	30	view →
KIRC	OS	Quartile	All	0.709	0.832	.001	29	view →
DLBC	OS	Median	II,III,IV	0.388	0.945	.015	21	view →
ACC	DFS	Quartile	All	0.181	0.599	.002	20	view →
MESO	OS	Quartile	All	0.414	0.614	.011	15	view →
LUAD	DFS	Tertile	IV	0.860	0.360	.043	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NKX2-2–KIRP (DFS)

Open the KIRP breakdown →