NKX2-2

Across TCGA patient cohorts, NKX2-2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and Ku80. Each is linked with NKX2-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-2-to-partner and partner-to-NKX2-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NKX2-2-low versus NKX2-2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-2→partner) and Y-score (partner→NKX2-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.216	-2.584	.024	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.177	-2.087	<.001	.005	3	2
UCEC	Ku80 →	+0.337	+2.598	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.144	-1.678	.011	.023	3	2
UCEC	PKC-b-II_pS660 →	-0.309	-2.584	.003	.010	3	2
UCEC	ATM →	-0.490	-2.446	.004	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by NKX2-2 expression — UCEC

Explore this box plot interactively →