NKX2-2

Across TCGA cell cohorts, NKX2-2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,978 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NKX2-2-associated GO terms across cancer lineages are Optic nerve development, ATP synthesis coupled electron transport, and Mitochondrial ATP synthesis coupled electron transport. Each is linked with NKX2-2 in more than 6 cancer types. Because this analysis shows association rather than direction, both NKX2-2-to-partner and partner-to-NKX2-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Optic nerve development grouped by NKX2-2-low versus NKX2-2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-2→partner) and Y-score (partner→NKX2-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Optic nerve development →	-0.289	-0.697	<.001	.004	3	7
BONE	ATP synthesis coupled electron transport →	+0.053	+2.535	.009	.001	3	6
BONE	Mitochondrial ATP synthesis coupled electron transport →	+0.053	+2.535	.009	.001	3	6
BONE	Mitochondrial electron transport, NADH to ubiquinone →	+0.090	+3.398	.002	<.001	3	6
BONE	Nephron morphogenesis →	-0.072	-3.339	.004	.001	3	5
BONE	Nephron epithelium morphogenesis →	-0.072	-3.339	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,978 associations by consensus.

Optic nerve development by NKX2-2 expression — SKIN

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