NKX2-2

Across TCGA cell cohorts, NKX2-2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX2-2-associated genes across cancer lineages are CNIH1, PPP1R17, and C2orf42. Each is linked with NKX2-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-2-to-partner and partner-to-NKX2-2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNIH1 grouped by NKX2-2-low versus NKX2-2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-2→partner) and Y-score (partner→NKX2-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNIH1 →	+0.576	+3.064	.001	.009	3	1
LARGE_INTESTINE	PPP1R17 →	+0.048	+2.560	<.001	.008	3	1
LARGE_INTESTINE	C2orf42 →	+0.630	+3.215	<.001	.009	3	1
LARGE_INTESTINE	TOPAZ1 →	+0.012	+3.415	<.001	.001	3	1
LARGE_INTESTINE	NR1D2 →	+1.118	+3.067	<.001	.009	3	1
LARGE_INTESTINE	C9orf153 →	+0.138	+3.497	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

CNIH1 by NKX2-2 expression — LARGE_INTESTINE

Explore this box plot interactively →