NKX2-1

Across TCGA pan-cancer cohorts, NKX2-1 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NKX2-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where NKX2-1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NKX2-1 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.

LSCC and LUAD are the cancer types where NKX2-1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX2-1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−1.603	<.001	9	view →
LUAD	Female	All	+0.557	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

NKX2-1–LSCC

Open the LSCC breakdown →