NKG7

Across TCGA patient cohorts, NKG7 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NKG7-associated genes across cancer lineages are HER2_pY1248, HER3_pY1289, and MAPK_pT202_Y204. Each is linked with NKG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKG7-to-partner and partner-to-NKG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER2_pY1248 grouped by NKG7-low versus NKG7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKG7→partner) and Y-score (partner→NKG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HER2_pY1248 →	-0.184	-3.000	.028	.036	1	1
SKCM	HER3_pY1289 →	-0.121	-2.982	.025	.036	1	1
SKCM	MAPK_pT202_Y204 →	+0.516	+3.000	.043	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

HER2_pY1248 by NKG7 expression — SKCM

Explore this box plot interactively →