NKAP

Across TCGA pan-cancer cohorts, NKAP mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NKAP data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NKAP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NKAP expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

HNSC, LSCC, and UCEC are the cancer types where NKAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.270	1.000	.021	12	view →
LSCC	DFS	Tertile	II,III,IV	0.314	1.000	.006	4	view →
UCEC	DFS	Quartile	All	0.963	0.731	.026	2	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	1	view →
LUAD	OS	Median	II,III,IV	0.998	0.864	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NKAP–HNSC (OS)

Open the HNSC breakdown →