NKAP

Across TCGA pan-cancer cohorts, NKAP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of NKAP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NKAP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKAP is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where NKAP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKAP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.624	<.001	12	view →
KIRC	Male	IV	+0.482	<.001	11	view →
LIHC	Male	II,III,IV	+1.125	<.001	9	view →
COAD	Male	All	+0.541	<.001	8	view →
STAD	All	II,III,IV	+0.616	<.001	7	view →
READ	All	All	+0.602	.002	7	view →
THCA	Male	III,IV	−0.258	<.001	7	view →
UCEC	All	All	−0.699	<.001	6	view →
CHOL	All	All	+1.181	<.001	3	view →
KICH	Female	All	−0.587	<.001	3	view →
ESCA	All	All	+0.569	.001	2	view →
KIRP	All	II,III,IV	+0.347	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

NKAP–HNSC

Open the HNSC breakdown →