NKAP

Across TCGA cell cohorts, NKAP mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKAP-associated genes across cancer lineages are FOLR2, OR5A1, and TRIM49C. Each is linked with NKAP in more than 1 cancer types. Because this analysis shows association rather than direction, both NKAP-to-partner and partner-to-NKAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOLR2 grouped by NKAP-low versus NKAP-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKAP→partner) and Y-score (partner→NKAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FOLR2 →	+0.061	+4.032	<.001	.004	3	1
SKIN	OR5A1 →	+0.012	+4.437	<.001	.004	3	1
SKIN	TRIM49C →	+0.051	+3.920	<.001	.005	3	1
SKIN	PRAMEF25 →	+0.074	+4.054	<.001	.004	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
LARGE_INTESTINE	GRM1 →	+0.029	+3.750	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

FOLR2 by NKAP expression — SKIN

Explore this box plot interactively →