Across TCGA pan-cancer cohorts, NKAIN1P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NKAIN1P1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NKAIN1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NKAIN1P1 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC and BRCA are the cancer types where NKAIN1P1 tumor–normal differential expression is most reproducible.