NIT2

Across TCGA cell cohorts, NIT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,579 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NIT2-associated GO terms across cancer lineages are Asparagine metabolic process, L-methionine salvage, and Protein insertion into mitochondrial outer membrane. Each is linked with NIT2 in more than 7 cancer types. Because this analysis shows association rather than direction, both NIT2-to-partner and partner-to-NIT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Asparagine metabolic process grouped by NIT2-low versus NIT2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NIT2→partner) and Y-score (partner→NIT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Asparagine metabolic process →	+0.178	+1.085	<.001	<.001	3	8
KIDNEY	L-methionine salvage →	+0.182	+0.637	<.001	.004	3	7
UPPER_AERODIGESTIVE_TRACT	Protein insertion into mitochondrial outer membrane →	+0.096	+0.831	<.001	<.001	3	7
KIDNEY	Amino acid salvage →	+0.182	+0.637	<.001	.004	3	7
CNS	L-methionine biosynthetic process →	+0.075	+0.496	.001	.006	3	6
PANCREAS	Aspartate family amino acid biosynthetic process →	+0.121	+0.616	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,579 associations by consensus.

Asparagine metabolic process by NIT2 expression — LUNG_SCLC

Explore this box plot interactively →