NISCH

Across TCGA patient cohorts, NISCH mutation is significantly associated with the RNA expression of many other genes, with 4,347 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NISCH-associated genes across cancer lineages are SEMG2, RDM1P1, and ASF1B. Each is linked with NISCH in more than 3 cancer types. Because this analysis shows association rather than direction, both NISCH-to-partner and partner-to-NISCH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEMG2 grouped by NISCH-low versus NISCH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NISCH→partner) and Y-score (partner→NISCH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SEMG2 →	+0.475	+2.789	.001	<.001	3	3
READ	RDM1P1 →	+0.068	+5.691	<.001	<.001	3	3
COAD	ASF1B →	+0.525	+3.331	.002	.005	3	3
UCEC	LMNB1 →	+0.514	+1.494	.003	.001	3	3
COAD	STIL →	+0.574	+2.598	.001	.006	3	3
UCEC	UHRF1 →	+0.658	+1.688	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,347 associations by consensus.

SEMG2 by NISCH expression — COAD

Explore this box plot interactively →