NIPSNAP3B

Across TCGA patient cohorts, NIPSNAP3B mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPSNAP3B-associated genes across cancer lineages are HNRNPMP2, TRAJ43, and VPS26B. Each is linked with NIPSNAP3B in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPSNAP3B-to-partner and partner-to-NIPSNAP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPMP2 grouped by NIPSNAP3B-low versus NIPSNAP3B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPSNAP3B→partner) and Y-score (partner→NIPSNAP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HNRNPMP2 →	+0.089	+6.147	<.001	.002	3	2
UCEC	TRAJ43 →	+0.675	+2.433	<.001	.001	3	2
UCEC	VPS26B →	+0.468	+3.354	.003	.005	3	1
UCEC	DDAH1 →	+0.734	+3.202	.008	.009	3	1
UCEC	MRPL39 →	+0.465	+2.711	.005	.003	3	1
UCEC	WHAMM →	+0.598	+3.353	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

HNRNPMP2 by NIPSNAP3B expression — BLCA

Explore this box plot interactively →