NIPSNAP3B

Across TCGA pan-cancer cohorts, NIPSNAP3B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated NIPSNAP3B data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher NIPSNAP3B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NIPSNAP3B expression acts as an unfavorable survival marker, although some lineages such as UVM and PAAD show a favorable association.

UVM, PAAD, and LGG are the cancer types where NIPSNAP3B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.826	0.376	<.001	90	view →
PAAD	DFS	Tertile	All	0.427	0.206	<.001	56	view →
LGG	OS	Median	All	0.855	0.933	<.001	52	view →
KIRC	DFS	Quartile	All	0.782	0.435	<.001	38	view →
UCS	DFS	Tertile	II,III,IV	0.518	0.164	.002	34	view →
LUAD	OS	Quartile	All	0.870	0.688	.002	26	view →
STAD	DFS	Median	All	0.480	0.617	.008	23	view →
CHOL	OS	Median	II,III,IV	0.907	0.428	.016	15	view →
SARC	DFS	Median	All	0.686	0.530	.001	15	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.568	.009	11	view →
ESCA	OS	Median	All	0.771	0.624	.032	11	view →
ACC	OS	Tertile	IV	0.927	0.440	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

NIPSNAP3B–UVM (DFS)

Open the UVM breakdown →