NIPSNAP3B

Across TCGA patient cohorts, NIPSNAP3B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPSNAP3B-associated genes across cancer lineages are ATM, p62 Lck ligand, and Rab25. Each is linked with NIPSNAP3B in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPSNAP3B-to-partner and partner-to-NIPSNAP3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NIPSNAP3B-low versus NIPSNAP3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPSNAP3B→partner) and Y-score (partner→NIPSNAP3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.652	-3.000	.002	.036	3	2
UCEC	p62 Lck ligand →	+0.354	+2.179	.019	.034	3	1
UCEC	Rab25 →	-0.306	-3.321	.048	.010	3	1
UCEC	Chk2 →	-0.253	-3.000	.020	.036	3	1
UCEC	c-Kit →	-0.230	-2.584	.034	.011	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.673	+3.179	.004	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ATM by NIPSNAP3B expression — UCEC

Explore this box plot interactively →