NIPSNAP2

Across TCGA patient cohorts, NIPSNAP2 mutation is significantly associated with the RNA expression of many other genes, with 1,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIPSNAP2-associated genes across cancer lineages are COPS8P1, TUBBP11, and SNORD112. Each is linked with NIPSNAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NIPSNAP2-to-partner and partner-to-NIPSNAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS8P1 grouped by NIPSNAP2-low versus NIPSNAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIPSNAP2→partner) and Y-score (partner→NIPSNAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COPS8P1 →	+0.118	+2.748	<.001	.001	3	2
SKCM	TUBBP11 →	+0.169	+3.979	<.001	.003	3	2
SKCM	SNORD112 →	+0.275	+4.199	.003	.009	3	2
UCEC	MIR574 →	+0.359	+2.148	.007	.006	3	2
UCEC	RNA5SP113 →	+0.643	+3.351	<.001	.004	3	2
STAD	RNU2-47P →	+0.483	+5.951	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,562 associations by consensus.

COPS8P1 by NIPSNAP2 expression — UCEC

Explore this box plot interactively →