NINL

Across TCGA patient cohorts, NINL mutation is significantly associated with the RNA expression of many other genes, with 3,619 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NINL-associated genes across cancer lineages are NSD2, NUSAP1, and WDR76. Each is linked with NINL in more than 4 cancer types. Because this analysis shows association rather than direction, both NINL-to-partner and partner-to-NINL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NSD2 grouped by NINL-low versus NINL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NINL→partner) and Y-score (partner→NINL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NSD2 →	+0.396	+1.103	.001	.009	3	5
UCEC	NUSAP1 →	+0.553	+2.091	<.001	<.001	3	5
UCEC	WDR76 →	+0.583	+1.565	<.001	<.001	3	4
STAD	EIF5A →	+0.842	+3.618	<.001	.001	3	4
UCEC	SGTA →	+0.443	+2.099	<.001	<.001	3	4
UCEC	TBC1D13 →	+0.323	+2.102	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,619 associations by consensus.

NSD2 by NINL expression — UCEC

Explore this box plot interactively →