NINL

Across TCGA pan-cancer cohorts, NINL RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NINL’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NINL RNA is repressed in tumor relative to normal tissue. In most cancer types NINL is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KIRP are the cancer types where NINL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NINL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.886	<.001	10	view →
KIRC	Male	All	−1.324	<.001	9	view →
KIRP	Male	All	−1.067	<.001	6	view →
CHOL	All	All	+2.098	<.001	5	view →
HNSC	All	All	+0.514	.011	5	view →
UCEC	All	III,IV	+0.927	.026	4	view →
LIHC	All	All	+0.421	.004	3	view →
PRAD	All	All	−0.629	<.001	2	view →
KICH	All	All	−0.515	.004	2	view →
LUSC	All	All	+0.359	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NINL–THCA

Open the THCA breakdown →