NINL

Across TCGA patient cohorts, NINL mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NINL-associated genes across cancer lineages are FoxM1, PCNA, and ASNS. Each is linked with NINL in more than 3 cancer types. Because this analysis shows association rather than direction, both NINL-to-partner and partner-to-NINL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by NINL-low versus NINL-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NINL→partner) and Y-score (partner→NINL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FoxM1 →	+0.356	+3.031	.002	.017	3	4
UCEC	PCNA →	+0.167	+1.321	.005	.010	3	4
STAD	ASNS →	+0.420	+2.321	.035	.034	3	3
STAD	Caspase-7-cleavedD198 →	+0.734	+2.321	.028	.034	3	3
COAD	EGFR_pY1173 →	+0.083	+1.779	.045	.049	3	3
UCEC	STAT3_pY705 →	-0.286	-1.633	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

FoxM1 by NINL expression — STAD

Explore this box plot interactively →