NINL

Across TCGA cell cohorts, NINL mutation is significantly associated with the RNA expression of many other genes, with 346 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NINL-associated genes across cancer lineages are P2RY12, RAB19, and GTF2A1L. Each is linked with NINL in more than 2 cancer types. Because this analysis shows association rather than direction, both NINL-to-partner and partner-to-NINL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY12 grouped by NINL-low versus NINL-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NINL→partner) and Y-score (partner→NINL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	P2RY12 →	+0.031	+4.029	.001	.009	3	3
BLOOD_Leukemia	RAB19 →	+0.396	+3.711	.006	.002	3	2
BLOOD_Leukemia	GTF2A1L →	+0.082	+3.534	.006	.005	3	2
SKIN	PI4K2B →	+0.577	+3.302	.002	.008	3	2
LARGE_INTESTINE	GPR63 →	+0.776	+3.459	<.001	.001	3	2
LARGE_INTESTINE	PPP3CC →	+0.674	+2.588	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 346 associations by consensus.

P2RY12 by NINL expression — OVARY

Explore this box plot interactively →