NIN

Across TCGA pan-cancer cohorts, NIN Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated NIN data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher NIN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NIN expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

MESO, UCEC, and UVM are the cancer types where NIN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	IV	0.036	0.602	<.001	39	view →
UCEC	DFS	Median	II,III,IV	0.908	0.425	.006	32	view →
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
THCA	DFS	Median	All	0.100	0.841	<.001	18	view →
KIRP	OS	Median	All	0.614	0.907	.002	15	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	12	view →
PRAD	DFS	Median	All	0.617	0.886	.012	6	view →
HNSC	DFS	Median	III,IV	0.246	0.598	.014	6	view →
LIHC	OS	Median	All	0.131	0.780	<.001	6	view →
COAD	OS	Median	III,IV	0.168	0.692	.043	4	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
SKCM	OS	Median	All	0.588	0.786	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

NIN–MESO (OS)

Open the MESO breakdown →