NIN

Across TCGA pan-cancer cohorts, NIN RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NIN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NIN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NIN is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and KIRC are the cancer types where NIN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NIN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.385	<.001	12	view →
LIHC	Female	II,III,IV	+1.492	<.001	9	view →
KIRC	All	All	+0.576	<.001	9	view →
KIRP	Female	All	+1.172	.001	8	view →
CHOL	All	All	+1.732	<.001	5	view →
KICH	Female	All	−1.146	<.001	5	view →
LUSC	Male	All	+0.423	<.001	4	view →
PRAD	All	All	+0.440	<.001	2	view →
THCA	Female	All	−0.369	.004	2	view →
COAD	All	All	−0.310	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NIN–HNSC

Open the HNSC breakdown →