NIN

Across TCGA pan-cancer cohorts, NIN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NIN data layer compared with 25 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NIN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NIN expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where NIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.848	0.464	.003	37	view →
HNSC	OS	Quartile	All	1.000	0.330	.024	10	view →
LUAD	DFS	Median	III,IV	0.285	0.709	.026	3	view →
GBM	OS	Tertile	All	0.291	0.508	.013	2	view →
LSCC	DFS	Median	All	0.905	1.000	.048	1	view →
PDAC	DFS	Quartile	All	0.717	0.853	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NIN–CCRCC (DFS)

Open the CCRCC breakdown →