NIN

Across TCGA patient cohorts, NIN mutation is significantly associated with the RNA expression of many other genes, with 6,288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NIN-associated genes across cancer lineages are PSMA3, SRP19, and MTHFD1. Each is linked with NIN in more than 4 cancer types. Because this analysis shows association rather than direction, both NIN-to-partner and partner-to-NIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA3 grouped by NIN-low versus NIN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIN→partner) and Y-score (partner→NIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMA3 →	+0.344	+2.352	.003	.003	3	5
CESC	SRP19 →	+0.440	+3.199	.002	.009	3	5
COAD	MTHFD1 →	+0.437	+2.967	<.001	<.001	3	4
UCEC	CMC2 →	+0.426	+1.736	<.001	<.001	3	4
STAD	ZWINT →	+0.677	+3.484	.005	.002	3	4
UCEC	MTA2 →	+0.337	+1.366	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,288 associations by consensus.

PSMA3 by NIN expression — COAD

Explore this box plot interactively →