NIN

Across TCGA cell cohorts, NIN mutation is significantly associated with the RNA expression of many other genes, with 1,026 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NIN-associated genes across cancer lineages are NLRP2B, OR1C1, and OR2L8. Each is linked with NIN in more than 1 cancer types. Because this analysis shows association rather than direction, both NIN-to-partner and partner-to-NIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP2B grouped by NIN-low versus NIN-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NIN→partner) and Y-score (partner→NIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	NLRP2B →	+0.078	+4.807	<.001	<.001	3	2
OVARY	OR1C1 →	+0.048	+3.736	<.001	.004	3	2
OVARY	OR2L8 →	+0.039	+3.865	<.001	.001	3	2
BLOOD_Lymphoma	SLC9A4 →	+1.455	+3.819	<.001	.003	3	2
BLOOD_Lymphoma	KRTAP3-3 →	+0.030	+4.247	<.001	.004	3	2
LARGE_INTESTINE	CBY1 →	+0.695	+2.829	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,026 associations by consensus.

NLRP2B by NIN expression — OVARY

Explore this box plot interactively →