NIFKP6

Across TCGA pan-cancer cohorts, NIFKP6 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NIFKP6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NIFKP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NIFKP6 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, STAD, and BLCA are the cancer types where NIFKP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NIFKP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.038	.001	6	view →
STAD	All	II,III,IV	+0.104	.001	4	view →
BLCA	All	All	+0.080	.015	3	view →
THCA	Male	All	−0.048	.011	3	view →
COAD	All	II,III,IV	+0.077	.014	2	view →
KIRC	Male	All	+0.028	.001	2	view →
BRCA	All	II,III,IV	+0.023	.032	2	view →
LUSC	Male	All	+0.066	.041	1	view →
LIHC	All	All	+0.009	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NIFKP6–HNSC

Open the HNSC breakdown →