NHSL1

Across TCGA cell cohorts, NHSL1 mutation is significantly associated with the RNA expression of many other genes, with 633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NHSL1-associated genes across cancer lineages are SLC5A8, ENOPH1, and KCNRG. Each is linked with NHSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHSL1-to-partner and partner-to-NHSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A8 grouped by NHSL1-low versus NHSL1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHSL1→partner) and Y-score (partner→NHSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC5A8 →	+0.092	+4.201	<.001	.001	3	2
LARGE_INTESTINE	ENOPH1 →	+0.454	+2.043	.003	.008	3	2
LARGE_INTESTINE	KCNRG →	+0.437	+2.043	.001	.008	3	2
OESOPHAGUS	HAO2 →	+0.064	+4.017	<.001	.007	3	1
OESOPHAGUS	C5orf67 →	+0.387	+4.017	<.001	.007	3	1
LUNG_NSCLC_LUAD	BPIFB3 →	+0.504	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 633 associations by consensus.

SLC5A8 by NHSL1 expression — BLOOD_Leukemia

Explore this box plot interactively →