NHS-AS1

Across TCGA pan-cancer cohorts, NHS-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated NHS-AS1 data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NHS-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NHS-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and BLCA show a favorable association.

STAD, ACC, and LIHC are the cancer types where NHS-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	III,IV	0.401	0.693	<.001	85	view →
ACC	DFS	Median	III,IV	0.672	0.080	<.001	73	view →
LIHC	DFS	Tertile	II,III,IV	0.072	0.431	<.001	63	view →
THCA	OS	Tertile	IV	0.720	1.000	.004	60	view →
KIRC	DFS	Median	All	0.501	0.740	<.001	53	view →
BLCA	OS	Quartile	All	0.670	0.370	.005	41	view →
PAAD	OS	Quartile	All	0.287	0.580	<.001	40	view →
KIRP	OS	Tertile	All	0.940	0.815	.005	23	view →
UCS	OS	Tertile	IV	0.225	0.569	.041	18	view →
SKCM	DFS	Tertile	II,III,IV	0.171	0.716	<.001	18	view →
LGG	OS	Tertile	All	0.995	0.886	.031	12	view →
PCPG	OS	Tertile	All	0.828	0.963	<.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

NHS-AS1–STAD (OS)

Open the STAD breakdown →